When multiple myeloma patients receive chemotherapy, the time of effect of chemotherapy is different due to different chemotherapy regimens as well as different factors such as patient’s age, physical condition, the presence of comorbidities and whether the patient has been retreated or not. 1. The induction chemotherapy regimen for multiple myeloma can be 4~6 cycles or 6~8 cycles, with different regimens and different sensitivities of patients to chemotherapy, the time of effect is also different. 2. Adverse reactions may also occur during chemotherapy. Patients with earlier disease staging, younger age, better physical condition and no other comorbidities will see the effect earlier, and the disease may even be relieved after 1 cycle of induction chemotherapy. However, if the patient is at a later stage of the disease, older, in poor physical condition, and has underlying comorbidities, multiple cycles of chemotherapy may be required to achieve remission, or even require a change in chemotherapy regimen. Therefore, there is no accurate data on how many times chemotherapy for multiple myeloma can be effective. Specific drugs include bortezomib, cyclophosphamide, lenalidomide, etc., and drug treatment should be carried out under the guidance of physicians.