Getting up in the morning with a bitter and smelly mouth may be caused by cholecystitis, periodontitis, bile reflux gastritis, and other diseases such as gingivitis. 1. cholecystitis: cholecystitis patients with poor gallbladder function may appear bile upwelling, the morning patients may appear bile reflux to the oral cavity will cause bitter mouth. In addition, bile and stomach contents reflux to the mouth may also cause bad breath. 2. Periodontitis: Periodontitis is mainly caused by plaque infection, and plaque in the mouth will secrete harmful substances and toxins, these substances will lead to bad taste in the mouth, and cause bitter mouth. In addition, periodontitis patients will also have periodontal swelling, bad breath and other manifestations, so the patient will get up in the morning after the mouth will have a bitter and smelly performance. 3. Bile reflux gastritis: patients with bile reflux gastritis will vomit yellow-green bile, and patients will also be accompanied by dyspepsia, belching, acid reflux and other manifestations, if the patient is often vomiting gastric contents and bile, may be in the morning after getting up after the symptoms of bitter and smelly mouth. 4. Other: Bitter and smelly mouth in the morning may also be caused by gingivitis, chronic gastritis, indigestion and other diseases. It is recommended that patients need to consult a doctor in a timely manner if they have a bitter and smelly mouth in the morning, and need to choose the appropriate measures for treatment under the guidance of the doctor.