Patients suffering from gynecological inflammation, the use of diazoxide suppositories vaginal and vulvar parts of the original itching symptoms more aggravated, this phenomenon may be mainly due to: 1, the patient’s condition is not suitable for the use of this drug, the use of the drug does not play a due therapeutic effect, the patient’s condition further aggravated, thus leading to vaginal and vulvar parts of the itching symptoms more obvious; 2, the patient of diazoxide suppositories of an allergic reaction to a certain 2, the patient has an allergic reaction to one of the ingredients in the Diazotide suppository, causing allergic symptoms in the vagina and vulva after the release of the drug, thus causing more serious itching symptoms in the vagina and vulva. Diazotide suppository is a kind of compound preparation containing metronidazole and clotrimazole, which is used for the treatment of mycotic vaginitis, trichomonas vaginitis, mixed vaginitis, bacterial vaginitis and other gynecological inflammatory diseases. Regardless of the reason for the worsening of local itching symptoms after the use of medication, it is necessary to consider stopping the use of medication, timely follow-up in the hospital, adjusting the therapeutic drugs.