Pearly penile papules, usually referred to as penile pearly papules, can be treated with general treatment, physical therapy, and medication. 1. General treatment: penile pearly pimples is a benign lesion, usually no conscious symptoms, can not be treated, but should strengthen the daily care, to keep the penis area clean, to avoid triggering infection. 2. Physical therapy: Because penile pearly papules will make the penile area appear granular material, which can make the appearance of the penis appear to change, some men may have psychological barriers, can be removed through physical therapy, such as cryotherapy, laser therapy. 3. medication: in the daily care is not appropriate, resulting in penile pearl rash infection, should also be used with topical anti-infective drugs for treatment, such as erythromycin ointment, mupirocin ointment, and so on. In the treatment period, should be carried out doctor’s orders, reasonable use of medication, to avoid incorrect use of drugs lead to adverse reactions.