Prostate psa value fluctuates up and down may be caused by a variety of factors such as fluctuating medical conditions or local irritation caused by prostate examination. The psa is a glycoprotein secreted by the prostate gland and is mainly found in the epithelial cells of the prostate ducts. psa is elevated in benign prostate diseases such as prostate hyperplasia and prostatitis, and can also be elevated in prostate cancer. As the condition changes, the psa value may also fluctuate. In addition, some prostate examinations, such as anal diagnosis, prostate massage, cystoscopy, etc., as well as prostate surgery will cause an increase in the release of psa from prostate tissues, which may result in a short-term increase in psa concentration, which may be lowered by reviewing a few days after the above examinations or operations. If the psa value of the prostate gland is persistently elevated, it is necessary to consult the doctor for examination and early treatment.