Benign breast nodules can be vaccinated with the third injection of New Crown. Patients with malignant manifestations and undergoing radiotherapy treatment should be deferred from vaccination. 1. Breast nodules per se have no effect on booster vaccination, and there is no evidence that the third injection will cause or aggravate breast nodules, so patients with breast nodules can receive the third injection. 2. Some patients who are taking medication for benign nodules should consult the vaccination unit to confirm that the medication they are taking has no effect on the vaccine before making an appointment for vaccination. 3. For patients with malignant breast nodules who are currently undergoing surgery or radiotherapy, vaccination should be postponed. Because more malignant nodules and chemotherapy drugs may aggravate the adverse effects of booster shots, vaccination should be postponed.