Gastric erosion belongs to the gastric aspect of the disease, mucosal lesions are relatively shallow ulcerative lesions. Ranitidine, omeprazole, bismuth potassium citrate and other drugs can be used to treat. Gastric erosion is due to excessive secretion of gastric acid will violate the gastric mucosa, in the treatment process need to use drugs to inhibit gastric acid secretion. Ranitidine can inhibit the secretion of gastric acid, reduce the concentration of gastric acid, and reduce the destruction of gastric mucosa by gastric acid. Omeprazole is a proton pump inhibitor, which can inhibit the activity of hydrogen ion proton pump, block the gastric acid secretion pathway, and have a longer-term inhibitory effect on gastric acid. If the patient’s gastric mucosa has been broken, drugs that promote the recovery of gastric mucosa, such as bismuth potassium citrate, need to be used to enter the stomach and attach to the mucosa of the digestive tract, which not only reduces the damage of gastric acid but also promotes mucosal mucus secretion, so that the mucosa can be restored as soon as possible. The indications, contraindications and adverse reactions of different drugs are different, and the most suitable drug should be selected by the doctor for treatment according to the severity of the patient’s condition and the therapeutic effect.