Colchicine and non-steroidal anti-inflammatory drugs (NSAIDs) can be used to reduce swelling and relieve pain during gouty attacks in the joints of the hands. 1. Colchicine: Colchicine plays the role of anti-inflammatory and analgesic by reducing inflammatory reaction and inhibiting inflammatory cell chemotaxis, starting to take the drug 12 hours before the onset of gout attack can get a better therapeutic effect, but the dosage of colchicine should be strictly controlled to alleviate the symptoms of gout. However, the dosage of colchicine should be strictly controlled. When using colchicine, it is necessary to pay attention to the occurrence of nausea, vomiting and other gastrointestinal adverse reactions. 2. Non-steroidal anti-inflammatory drugs: Non-steroidal anti-inflammatory drugs such as nimesulide, etoricoxib, celecoxib, indomethacin and so on can play the role of anti-inflammatory and pain relief by inhibiting prostaglandin synthesis, but the use of this kind of drugs need to be vigilant about the risk of gastrointestinal tract ulcers, bleeding and perforation. Drugs should be used under the guidance of a physician, and gout patients are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation and treatment as prescribed by the doctor.