Hiccup is the common name for eructation, and some people infected with Helicobacter pylori can have the symptom of eructation, while some have no obvious symptoms. After H. pylori parasitizes the gastric mucosal tissue, it can secrete urease, protease and other pathogenic factors, leading to gastric mucosal damage. When H. pylori infection has not progressed to other diseases, some patients may experience a variety of gastrointestinal discomforts, including hiccups. Upset is not a specific manifestation of H. pylori infection, and some patients who do not have the symptom of upsets may present with other symptoms, such as acid reflux, poor appetite, and intermittent abdominal pain. There are also some patients who have no obvious clinical symptoms. Therefore, there are individual differences in the symptoms of H. pylori infection, and it is recommended to consult a doctor as soon as it is detected, so as to avoid the development of gastritis, gastric ulcer or even gastric cancer and other diseases.