Pain in the middle of the chest may be an adverse symptom caused by pleurisy, and such discomfort may also occur when suffering from costochondritis, reflux esophagitis, etc. It is recommended to consult a doctor for examination in time. 1. Pleurisy: Pleurisy will cause pain in the middle of the chest, and the pain will be more obvious when the patient takes a deep breath or coughs vigorously, which may be accompanied by chest tightness, fatigue and other symptoms, and some patients may have fever. 2. Costochondritis: pain in the middle of the chest may also be discomfort caused by costochondritis, redness and swelling may appear around the chest, which may also cause acidity, swelling, pressure and pain and other symptoms, and after strenuous exercise, the discomfort will be more intense. 3. Reflux esophagitis: Reflux esophagitis can also cause this kind of discomfort, and also cause acid reflux, heartburn and other adverse symptoms, the patient’s throat may appear foreign body sensation, some patients will have difficulty swallowing, and severe esophageal stenosis may be caused. In addition, pain in the middle of the chest may also be the discomfort caused by coronary heart disease, patients will have chest tightness and shortness of breath, arrhythmia, dyspnea and other adverse symptoms, which will cause physical fatigue, limb weakness and other discomforts, and some patients will have a shock situation. This kind of situation requires timely medical examination, according to the results of the examination, under the guidance of the doctor’s advice to actively cooperate with the treatment.