Gouty arthritis affects mostly males, with the first metatarsophalangeal joint or tarsal joint being the most common site of arthritis. The pain is severe and cannot be palpated. It can also affect the ankle, knee, wrist and finger joints. Repeated acute attacks may occur in two or more joints at the same time. Due to persistent hyperuricemia. Uric acid is deposited near the joints or under the skin, forming gout nodules. The nodules gradually increase in size, resulting in local deformity and bone destruction. Needle-shaped uric acid crystals can be seen on joint cavity puncture or nodule biopsy. Rheumatoid arthritis occurs mostly in adolescents, and the disease is most often associated with a history of upper respiratory tract streptococcal infections such as sore throat or tonsils. The typical arthritis is wandering and polymorphic. It affects several large joints simultaneously, with knee, ankle, elbow, wrist and shoulder joints being the most common. In acute attacks, the affected joints are red, swollen, burning, painful, and painful, and movement is limited. No joint deformity remains after the acute phase. The efficacy of anti-streptococcal hemolysin O is increased, while the rheumatoid factor is negative, and the effect of adequate salicylic acid preparation is rapid and significant.