Sweat vesicles are usually cured within a few weeks after an attack, but in a few cases they can recur and even develop into chronic eczema with combined or concurrent bacterial-fungal infections, so reducing the patient’s pain as well as minimizing complications is the main goal of treatment. Avoid mental stress and mood swings, and look for and get rid of contact irritants. Sweaty hands and feet should be treated appropriately, avoid scalding and scratching, and keep the skin of hands and feet dry. Local drug treatment is based on the principles of dryness, anti-inflammation and antipruritic. Early on, we can consider using compound preparations with anti-inflammatory, antipruritic and antibacterial effects such as Paregoric and Trimethoprim; when blistering and inflammation are obvious, we can consider using herbal lotions with astringent and antipruritic effects and clearing heat; we can also take oral antihistamines and Chinese medicines with clearing heat and relieving itch. When the disease is mainly flaking and dry skin in the late stage, urea cream or moisturizer can be used.