There are many reasons for waking up at four o’clock and not being able to sleep, such as insomnia symptoms, biological clock disorders, neuropsychiatric diseases, cerebral arteriosclerosis, acute hypertension, etc. It is recommended that patients go to the hospital in a timely manner and be treated under the guidance of a doctor. 1, insomnia symptoms: patients waking up at four o’clock in the morning and not being able to sleep belongs to the early awakening of sleep disorders, i.e. insomnia symptoms, the first consideration of this symptom is due to the things considered during the day Too much or mental tension, stress caused by; 2, biological clock disorders: If patients often stay up late or irregular rest and rest lead to biological clock disorders, such as patients in the middle of the night when waking up always like to look at the phone, play games, etc., it is easy to lead to brain nerve disorders, the patient’s biological clock is disrupted is easy to always wake up at four o’clock can not sleep; 3, neuropsychiatric diseases: neurological disorders patients mostly due to the usual Mental tension, stress, can appear at four o’clock in the morning waking up sleeplessness. In addition, the symptoms can also appear in patients suffering from neurological diseases such as dementia, Parkinson’s disease, familial insomnia, also seen in patients with depression, schizophrenia, etc.; 4, other: the existence of cerebral arteriosclerosis, acute hypertension, coronary heart disease, congestive heart failure, chronic renal failure and endocrine diseases, infections and other diseases, due to the impact of disease, may also lead to four o’clock in the morning waking up sleepless, at this time Patients are recommended to go to the neurology department of the hospital in time to identify the causes and treat the symptoms to avoid delay.