How long patients with stage III myeloma live is mostly related to the patient’s age, tumor biology and treatment. Survival time is highly variable, mostly between 6 months and 3 years. With the application of new drugs and the continuous improvement of medical measures, the survival time of myeloma patients has been significantly prolonged, and currently, the median survival time can reach about five years, but it is still an incurable disease. Generally the older the age, the shorter the survival time. Myeloma stage III generally belongs to the advanced stage of myeloma, without treatment, the median survival can be only six months, and the median survival of most patients with conventional chemotherapy will not exceed three years. Survival is relatively short, and death often occurs due to renal impairment, infection, etc. Therefore, the complications in this stage are complicated, and attention should be paid to regular review, symptomatic care, and standardized treatment.