Plasmacytoid adenocarcinoma is a malignant tumor in clinic, which is usually caused by estrogen stimulation without progesterone counteracting for a long period of time, and the treatment effect is relatively poor. Plasmacytoid adenocarcinoma belongs to one kind of ovarian malignant tumor, which is a more common type of malignant tissue with strong proliferative property. This kind of disease is commonly found in middle-aged and old-aged women, with relatively high deterioration degree, and the early symptom is not too obvious, which is often mistaken for ascites and abdominal distension for diagnosis and treatment. Uterine plasmacytoid carcinoma may be caused by long-term estrogen stimulation of the endometrium due to long-term use of estrogen drugs. It is recommended to go to the hospital for a detailed physical examination in time when abnormalities occur, which can be determined by endometrial biopsy. It should be noted that patients with plasma adenocarcinoma can reduce the adverse effects of the disease through “early detection, early diagnosis and early treatment”, and many of them may survive for a long time, so it is recommended that patients establish confidence in treatment.