HPV vaccine refers to human papillomavirus, HPV2 bivalent vaccine and HPV quadrivalent vaccine are both applicable to women aged 9-45 years old, the difference is that the preventive virus types are different, the vaccination program is different and so on. 1. Different types of preventive viruses: HPV bivalent vaccine mainly prevents HPV16 subtype, HPV18 subtype two HPV high-risk types of viral infections, mainly for cervical cancer. The HPV quadrivalent vaccine, in addition to HPV16 and HPV18 subtypes, also has two subtypes, HPV11 and HPV6, which are targeted at warts. 2. Vaccination time is different: generally HPV bivalent vaccine needs to be in 0, 1, 6 months, each receiving a shot. The HPV quadrivalent vaccine, on the other hand, needs to be in 0, 2, 6 months, each receiving a shot. It is recommended that HPV 2-valent vaccine and HPV 4-valent vaccine can be vaccinated under the guidance of a doctor. In addition, women who have sex need to undergo cervical cytology screening and HPV examination before HPV vaccination.