High globulins are common in chronic liver disease, M-globulinemia, autoimmune diseases, chronic inflammation and infection. Total serum proteins are divided into serum proteins and globulins. Globulins are mixtures of proteins, including high levels of immunoglobulins and complements, multiple glycoproteins, metal-binding proteins, various lipoproteins and enzymes. Globulin is closely related to the immune function of the body. The reference value of globulin in normal people is 20-30g/L, when globulin>35g/L is called hyperglobulinemia, the main reasons for elevated globulin are. 1. Chronic liver disease: including autoimmune chronic hepatitis, chronic active hepatitis, cirrhosis, chronic alcoholic liver disease, primary biliary cirrhosis, etc. The degree of elevation is related to the severity of liver disease. 2. M-globulinemia: e.g., multiple myeloma, lymphoma, primary macroglobulinemia. 3. Autoimmune diseases: such as systemic lupus erythematosus, rheumatic fever, rheumatoid arthritis. 4. Chronic inflammation and infection: such as tuberculosis, malaria, black fever, etc. When elevated globulin is detected, it is recommended to consult a doctor for further investigation and diagnosis in order to avoid delaying the condition.