Down screening 21 high risk to do non-invasive may be over, there is a possibility that not, if there is a problem with the screening need to further amniocentesis to clarify the diagnosis. Down screening 21 high risk indicates that there is a risk of trisomy 21, but the Down screening is only a preliminary screening, can not be used as a basis for a definitive diagnosis, the need for further non-invasive DNA screening or direct amniocentesis for a definitive diagnosis, non-invasive DNA test usually have two situations: 1. can pass: Down screening 21 high-risk pass, non-invasive DNA test suggests no high risk of trisomy 21, you can continue to pregnancy, need to do a good four-dimensional ultrasound macro-anomalies and other tests in the late period of regular pregnancy checks. 2. There is a risk of trisomy 21: Down screening 21 high-risk through non-invasive DNA test suggests that there is a high risk, you can further do amniocentesis for a clear diagnosis, if the diagnosis is fetal chromosomal abnormality, there is a high risk of trisomy 21, you need to terminate the pregnancy in a timely manner.