If the transaminases are more than twice the normal value, chemotherapy should be more cautious. For example, for some tumors that are particularly sensitive to chemotherapy and liver damage caused by tumors, chemotherapy can be administered by drug reduction during the treatment period, but this method is not particularly common. Generally speaking, we still hope that it is safer to do chemotherapy when the liver function, kidney function and blood count are normal and there are no obvious contraindications to chemotherapy. If the liver function is particularly serious, such as some patients with severe chronic hepatitis B, the risk of chemotherapy is very high, which may cause severe hepatitis or cause further damage to liver function. Therefore, in general, we want to be cautious when the transaminases reach more than 2 times. Chemotherapy is safer when the liver function (transaminases) is less than 2 times or when the liver function transaminases are normal.