Normal menstruation is once in 28-30 days, even at the age of 45, as long as the hormone level is normal it will not come 2 times a month, the causes will be more. First, when there is endocrine hormone imbalance, when the ovarian function decreases, it will be accompanied by a decrease in estrogen and progesterone, which cannot meet the normal needs of the body, it will cause abnormal bleeding during the non-menstrual period. At this time, the endocrine hormones must be checked on an empty stomach and medication should be administered according to the situation. When there are uterine fibroids, endometrial polyps, submucosal fibroids, including bilateral ovarian cysts, it will also cause abnormal bleeding during non-menstrual period, then surgery should be used to treat the situation. Third, when there is a viral infection of the cervix, infection with human papillomavirus can also cause abnormal bleeding, so if necessary, TCT and HPV anti-AIDS tests are required.