Clozapine, as a second-generation antipsychotic drug, its application must be under the guidance of a doctor, according to the patient’s condition and the side effects of the drug slowly and gradually increase the dosage, and its dosage of more than 300mg/d needs to be taken in divided doses. Clozapine can be taken up to 12 tablets per night.
Clozapine is taken orally in small doses, the first dose of 25mg (1 tablet), 2-3 times a day, and gradually and slowly increased to the usual therapeutic dose of 0.2-0.4g (8-16 tablets) a day, and a high dose of up to 0.6g (24 tablets) a day. The maintenance dose is 0.1-0.2g (4-8 tablets) a day.
1. Clozapine, as a second-generation antipsychotic, is recommended for the treatment of refractory schizophrenia or schizophrenia with suicidality or intolerance of extrapyramidal adverse effects. It is effective in both positive and negative symptoms of schizophrenia.
2. Its dosage is given in a gradual incremental way according to the patient’s condition and side effects of the drug. The starting dose is 25mg, 2~3 times a day, increasing 25~50mg daily until the efficacy is satisfactory; the maintenance dose is 300~450mg/d, more than 300mg/d dose needs to be divided into doses; more than 450mg/d dose needs to be spaced out for a week, and the maximum dose is 600mg/d.
3. Clozapine has the side effects of postural hypotension, excessive sedation, granulocytopenia, and also has the effect on the metabolism of blood glucose and blood lipids, and it is necessary to monitor the blood concentration in the course of treatment.
Clozapine is a prescription drug, the use of which must be in accordance with medical advice, not self-medication, to avoid serious side effects.