In case of bitter lips, it is usually associated with bile reflux. Under normal circumstances, bile can enter the duodenum through the bile duct and then enter the small intestine to participate in food digestion, mainly in fatty foods. If the patient’s gastrointestinal tract function is restricted or there are pathological changes that make the bile retrograde peristalsis and enter the stomach and mouth, and then the feeling of bitter lips occurs. If the patient has symptoms of bile reflux, the symptoms can be eliminated by appropriate methods and treatments. In daily life, it is recommended to eat a diet based on vegetables and fruits, including leeks, celery, bananas and apples, which can promote the peristalsis of the gastrointestinal tract and facilitate absorption and digestion. In addition, patients can apply drugs that promote gastrointestinal motility, such as morpholine, to reduce gastrointestinal retroperistalsis and normalize bile secretion. In addition, patients can effectively control their symptoms through physical exercise and mood regulation. If depression and stress can cause bile reflux, then it is a functional lesion.