Taking Cephalosporin and drinking alcohol can cause disulfiram-like reaction, which manifests as facial flushing, headache, dizziness, abdominal pain, nausea, vomiting, chest tightness, palpitations and other symptoms, and in severe cases, a drop in blood pressure, tachycardia, respiratory distress, and even life-threatening. Cephalosporin is a generic term for cephalosporin antibiotics with broad-spectrum antimicrobial effects, and it is usually forbidden to drink alcohol or consume alcohol-containing medications and food for three days before or seven days after the medication is given to avoid causing a disulfiram-like reaction. The disulfiram-like reaction is a reaction due to the inhibition of the enzyme acetaldehyde dehydrogenase by disulfiram, which leads to a large accumulation of acetaldehyde, thus causing acetaldehyde poisoning. Once the disulfiram-like reaction occurs, immediately stop taking medication or drinking alcohol, keep breathing well, seek medical attention as soon as possible, and induce vomiting or gastric lavage under the guidance of the doctor. Severe patients are given medication, such as dexamethasone and other hormonal drugs or injectable naloxone hydrochloride. If you eat cephalosporin drink after the disulfiram-like reaction of patients, it is recommended to consult a professional doctor, follow the doctor’s instructions to standardize the treatment, do not feel free to blindly use the drug.