Medications are the basis of treatment for bipolar disorder. Medications can control manic and depressive symptoms, and also prevent relapse. Just like diabetic patients need insulin to maintain the stability of blood sugar for a long time, bipolar patients also need medication to maintain the stability of mind for a long time.1.Lithium salt: the first-line medication for bipolar disorder, is the classical medication for bipolar disorder, which can treat both manic episodes and bipolar depression, but the effect on mixed episodes is slightly weaker. Lithium salt needs to be increased to therapeutic dose in 1-2 weeks. (1) Medication matters: Regularly test the blood concentration to ensure that the dose taken is within the effective range, because too high a dose can produce toxic side effects. Blood levels should be measured every 1-2 weeks. After the dose has stabilized, testing every two to three months is sufficient. Because many conditions can affect the drug concentration of lithium salts, it is also important to test the drug concentration if you change to a different brand of medication. (2) Conditions affecting lithium salt concentration include: weight gain or loss, salt consumption, seasonal changes (will increase in summer), other drug effects, such as painkillers ibuprofen, diuretics, cardiovascular drugs; tea, coffee; dehydration status; hormonal fluctuations during the menstrual cycle and pregnancy; somatic diseases, etc. 2, anticonvulsants: most of the anticonvulsants can be used as mood stabilizers to treat bipolar disorder. Valproate (magnesium valproate or sodium valproate) is a very effective mood stabilizer and is the first choice for rapid cycling, mixed episodes or mania with hallucinatory delusions. 3. Other anticonvulsants: carbamazepine, lamotrigine, topiramate (Tolte) 4. Atypical antipsychotics: Atypical antipsychotics are also being gradually used in the treatment of bipolar disorder. Olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone, etc. Olanzapine and fluoxetine combination. 5.Other: benzodiazepines, calcium channel blockers, thyroid drugs, etc. 6, antidepressants: antidepressants for bipolar depressive episode has been controversial. If bipolar depression must be applied to antidepressants, it must be combined with the mood stabilizer lithium or valproate combination. The application of antidepressants alone for bipolar disorder is likely to induce mania.