Sitting on the buttock pain needs to be treated according to the cause, generally common causes are muscle strain, sciatica, sciatic tuberosity bursitis, etc., the treatment includes general, physical therapy, drugs, surgery and so on. 1. Muscle strain: mainly due to prolonged sedentary or heavy physical labor, lumbosacral or sacrococcygeal muscle strain, manifested as localized soreness or tingling, concentrated in the sacrococcygeal area. It can be relieved by applying hot compresses and avoiding prolonged sitting and heavy physical labor. 2. Sciatica: mostly caused by lumbar disc herniation, can take non-steroidal anti-inflammatory drugs, such as ibuprofen, diclofenac sodium, etc., and more bed rest. 3. Sciatic tuberosity bursitis: inflammatory changes occur between the sciatic tuberosity and the surrounding soft tissues, triggering pain when sitting on the buttocks, and a clear and soft lump can be touched on the buttocks. It can be treated with hot compresses, massage, physical therapy, and surgery if necessary. Lead to a sit on the buttock pain may also have other reasons, such as sacrococcygeal fascia inflammation, etc., it is recommended to go to the hospital in a timely manner, the above drugs are recommended to use under the guidance of a doctor.