IgA nephrotic syndrome, a nephrotic syndrome caused by IgA nephropathy. The pathology manifests as deposition of immune complexes mainly immunoglobulin A (IgA) in the tethered zone, and the clinical manifestations are hematuria, proteinuria, edema, and hypertension, which need to be actively sought for treatment. IgA nephropathy is a chronic glomerulonephritis caused by abnormal deposition of IgA in the glomerular thylakoid zone, which is pathologically characterized by thylakoid hyperplasia and deposition of immune complexes in the thylakoid zone predominantly with IgA. It is the most common primary glomerular disease in China. Clinically, it can manifest as nephrotic syndrome, i.e., massive proteinuria and hypoproteinemia. IgA nephropathy is immune complex nephritis, and its pathogenesis is related to immune, genetic and other factors. After diagnosis, generally need to apply RASS system blockers, hormones and immunosuppressant treatment, such as Benadryl, Valsartan, Prednisone Acetate, Meconium Sodium Tablets, Hydroxychloroquine and other drugs. All of the above drugs should be used under the guidance of a doctor. It is recommended that patients go to regular hospitals in a timely manner and receive standardized treatment under the guidance of a physician.