Lamotrigine tablets can cause side effects such as dizziness, headache, fatigue, mania, rash, asthenia, etc. They are contraindicated in people who are allergic to the drug as well as in pregnant women. It is forbidden to use in combination with methoestradiol, and used with caution when combined with sedative-hypnotic drugs. Lamotrigine acts as an application-dependent blocker of voltage-gated sodium channels and is effective against seizures. Common side effects include dizziness, headache (2.8%), nausea, vomiting (2.5%), malaise (2.4%), mania (2%), amblyopia (2-5%), and rash (3%). Uncommon side effects are numerous and include abnormalities in various systems. Such as slowed ventricular conduction, neutropenia/leukopenia/thrombocytopenia, suicidal behavior and thoughts, tremor, ataxia, insomnia, arthralgia, dyspepsia, peripheral edema, hypersexuality, hypertension, syncope, and fungal dermatitis. Rare side effects include palpitations (rapid heartbeat, often accompanied by panic), dysphagia, vomiting of blood, black stools, gastrointestinal ulcers/bleeding, severe blood markers abnormalities, and grand mal convulsions. Lamotrigine is contraindicated in people who are allergic to the product, as well as pregnant women, is prohibited in combination with methoestradiol, and should be used with caution when combined with sedative-hypnotic drugs. The use of specific drugs must strictly follow the guidance of clinicians to avoid serious adverse effects.