Patients with sore and uncomfortable legs in the middle of the night commonly have the following causes: First, lumbar spine lesions: such as lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis, etc., can stimulate the nerves and cause clinical symptoms of sore legs in the middle of the night, most of which occur in the initial stage of the lesion. At this stage, the lumbar pain is also mild, and there is no obvious limitation of lumbar spine activities, only the symptoms of soreness, difficulty and discomfort in the legs, and the lesions of the lumbar spine can be detected by MRI or CT scan. Second, serious strain of leg muscles or cold: clinical symptoms of sore and uncomfortable legs in the middle of the night can also occur, accompanied by leg weakness performance, after early diagnosis and early treatment, the clinical symptoms of sore legs in the middle of the night can be relieved. Patients should strengthen the exercise of lumbar spine and leg muscles to avoid lumbar spine lesion and leg muscle strain, so as to prevent the occurrence of clinical symptoms of leg pain and difficulty.