Myeloma generally refers to multiple myeloma, which is a malignant proliferative disease of plasma cells, not a benign disease, characterized by bone damage, anemia, hypercalcemia. 1. Bone damage: bone pain is the main symptom, most common in the lumbosacral region, and those with severe pain after sprains are at risk of pathological fractures. 2. Anemia: because of the slow onset of anemia, the symptoms of anemia are not obvious, and most of them are mild or moderate anemia. The occurrence of anemia is mainly due to the decrease of erythropoiesis, which is related to the infiltration of myeloma cells and the inhibition of hematopoiesis. 3. Hypercalcemia: symptoms such as lack of appetite, vomiting and fatigue are mainly caused by extensive osteolytic changes and renal insufficiency. If the above symptoms appear, it is recommended to seek medical treatment in time, early detection and early treatment, so as to avoid delaying the condition.