Hidden pain in the middle of the chest may be caused by digestive system diseases, heart diseases, pleurisy, tumors, etc. General treatment, medication, surgery, etc. can be used, and medication should be followed by doctor’s advice. 1. Digestive system diseases: such as reflux esophagitis, gastric acid stimulation of the esophageal mucosa causes pain in the middle of the chest, which can be treated by correcting bad habits, such as avoiding lying down after meals, and using medicines to promote digestion, such as Panlidone tablets. 2. Heart disease: Coronary heart disease caused by narrowing or occlusion of coronary arteries can be manifested as chest pain and tightness in the chest. Nitrate drugs can be taken, such as sublingual nitroglycerin. The condition requires feasible surgical treatment, including percutaneous coronary intervention, coronary artery bypass grafting and so on. 3. Pleurisy: pleurisy is caused by lung infection, which manifests as chest pain and chest tightness. Sensitive antibiotics, such as cefuroxime, can be used according to the drug sensitivity test. When the disease is serious, surgical treatment can be taken, such as resection of infected lesions. 4. Tumor: such as lung tumor can cause hidden pain in the middle of chest. If it is a benign tumor, it can be surgically removed. If it is a malignant tumor, radiotherapy or chemotherapy should be carried out according to the doctor’s instruction to avoid further spread of the tumor, and chemotherapy drugs such as cisplatin can be used. Patients should seek medical treatment in time after the symptoms of chest pain, so as to avoid delaying the condition. Drugs should be used under the guidance of doctors, avoid self-medication.