Symptoms of lung adenocarcinoma in middle and late stages include cough, chest pain, hemoptysis and other lung manifestations, as well as brain metastasis, bone and joint metastasis and other metastases outside the chest. In the middle and late stage of lung adenocarcinoma, cough is the most common symptom, which can be manifested as irritating cough; hemoptysis, which can be manifested as persistent or intermittent blood in sputum; and it can be accompanied by chest pain, localized wheezing, emaciation, fatigue, anemia and other symptoms. Lung adenocarcinoma in advanced stage can have symptoms of metastasis outside the chest, such as brain metastasis, headache, vomiting, mental abnormality, etc. Bone and joint metastasis can have pain in metastatic site, and abdominal metastasis can have constipation and abdominal pain. If you have similar symptoms of lung adenocarcinoma, it is recommended to go to the hospital and ask the doctor to make a comprehensive judgment based on the specific situation and symptoms.