Urine protein plus or minus, suggests that there is a small amount of protein in the urine, may be functional proteinuria, and may be caused by primary kidney disease and secondary kidney disease and other factors. 1. Functional proteinuria: for example, strenuous exercise, mental stress, dietary factors, etc., may lead to the presence of a small amount of protein in the urine, resulting in proteinuria, but there are no other abnormalities, after the elimination of the above triggers, usually return to normal on their own. 2. Primary kidney disease: for example, acute nephritis, nephrotic syndrome, etc., which may lead to abnormal filtration function of the kidneys, and protein molecules will enter into the urine, which can cause proteinuria, and may be accompanied by swelling of the lower limbs, eyelid swelling and other symptoms. 3. secondary kidney disease: for example, diabetes, hypertension, allergic purpura, etc., after aggravation of the lesion, it may affect the renal function, resulting in renal lesions, it is easy to cause proteinuria. Patients with urinary protein plus or minus, it is recommended to go to the regular hospital, further improve the relevant examination, to clarify the specific causes, timely treatment, to avoid the continued aggravation of the lesions.