The main battleground for the future of cardiovascular disease will be the treatment of atrial fibrillation and heart failure. Currently, the main treatment for AF is still oral medication. Depending on the type of atrial fibrillation, there will be some differences in the oral medications that patients take, and the principles of treatment will also change. Today we talk about what drugs to take for atrial fibrillation? The important principle in the treatment of atrial fibrillation is to actively prevent thromboembolism embolism, reversal and maintenance of sinus rhythm, as well as control of the ventricular rate. Anticoagulant therapy is currently relatively widely used, mainly warfarin, but it requires regular monitoring of the prothrombin time international standardized, ratio of this drug can also be affected by the food that the patient eats, as well as other drugs. For patients with non-valvular AF, newer oral anticoagulants may be recommended, mainly dabigatran, apixaban, and rivaroxaban. For reversal of atrial fibrillation the main drugs are propafenone, amiodarone, ibutilide and so on. If the patient is in permanent atrial fibrillation and cannot undergo reversal of sinus rhythm, then the patient is advised to keep the ventricular rate under control. In patients with asymptomatic atrial fibrillation, it is recommended that the ventricular rate should be less than 110 beats per minute at rest. In the case of symptomatic or tachycardic cardiomyopathy, the resting heart rate should be less than 80 beats/minute, and after moderate exercise, the heart rate should be less than 110 beats/minute. Drugs commonly used clinically to control ventricular rate include beta-blockers, digitalis drugs, and calcium antagonists. Patients with atrial fibrillation should first identify the cause of the arrhythmia, and for uncorrectable atrial fibrillation, they must actively take oral medication to maintain it, and pay attention to regular review.