Hand, foot and mouth disease and chickenpox are usually not easy to get at the same time, but if the patient is exposed to both viruses at the same time, this situation may also occur. 1. Hand, foot and mouth disease: it is an acute febrile rash infectious disease caused by enterovirus. Early in the disease, patients will have symptoms such as low-grade fever, abdominal pain, fatigue, decreased appetite, etc., followed by painful blisters on the oral mucosa, and the appearance of red patches, pimples and blisters on the skin of the hands, feet and other parts of the body. 2. Chickenpox: It is a contagious skin disease caused by varicella zoster virus, which will lead to symptoms such as papules, blisters and blotchy rash on the skin of the whole body. In general, the phenomenon of hand-foot-mouth disease and chickenpox infection at the same time is very rare in clinical practice, but we can not rule out individual special circumstances, such as patients with low immunity and exposure to two viruses at the same time, there may be hand-foot-mouth and chickenpox at the same time phenomenon. Whether the patient is infected with hand-foot-mouth disease or chickenpox, it is recommended to go to the hospital in a timely manner, strictly comply with the doctor’s instructions during the treatment of medication, and at the same time to do a good job of home isolation, to prevent the transmission of infection to others.