Gastrointestinal mesenchymal stromal tumor will have the following complications after surgery: incision infection, lung infection, postoperative bleeding, anastomotic fistula, delayed gastric emptying and intestinal obstruction. 1. Incision infection: it is one of the common complications of this surgery. After the surgery, pay attention to clean the incision regularly and keep the incision clean and dry so as not to cause incision infection. 2. Lung infection: it mostly occurs in the old and frail people, especially those who have been bedridden for a long time. After the operation, assist the patients to turn over, and at the same time, encourage the patients to learn how to breathe and take deep breaths, so as to effectively expand the lungs, so as not to lead to lung infections. Reducing bed rest time is one of the key methods of prevention. 3. Postoperative bleeding: it is necessary to fully assess the patient’s coagulation function before surgery, and rely on the doctor’s good hemostatic ligation during surgery. 4. Anastomotic fistula: the surgeon needs to suture well during the operation, and nursing interventions can be used in the postoperative period to prevent complications. 5. Delayed gastric emptying and intestinal obstruction: mainly manifested as abdominal distension, abdominal pain, anal stop defecation and exhaustion, it is recommended to go down to the ground as early as possible to reduce the occurrence of this complication. Surgical total resection of gastrointestinal mesenchymal stromal tumor is a commonly used treatment method, which has the effect of resecting the tumor lesion, inhibiting further infiltration and metastasis, improving the survival rate and reducing the recurrence rate. Postoperative complications of gastrointestinal mesenchymal tumors can be reduced by adequate preoperative evaluation, excellent intraoperative technique, adequate postoperative care can reduce postoperative complications, and inform the doctor in time if postoperative discomfort occurs.