A bump next to the life line in the palm of the hand may be associated with tendon sheath cysts, skin boils, and congenital malformations of the bones. 1. Tendon sheath cysts are cystic lesions that occur in the tendon sheaths and are often associated with trauma or overstrain, and clinically appear as a small mass that protrudes slightly from the skin surface and is not painful when pressed; a cystic mass may be detected by ultrasound. 2. Skin boil: it is an acute infectious disease that occurs in the deep part of hair follicles, which is mainly manifested as small lumps under the skin, and there is obvious pain and redness. 3. Congenital deformities of the skeleton: they can also lead to the appearance of small localized bumps, which can be clearly diagnosed by X-ray examination. Due to the complexity of the cause, it is recommended that the patient go to the hospital in time, complete the examination to clarify the cause of the disease, and then treat the symptoms under the guidance of the doctor.