At this stage, there is no such thing as a cream that can get rid of blemishes with a single application. Comparatively speaking, effective medicines for pigmentation mainly include retinoic acid (retinoic acid ointment), depigmenting agent (hydroquinone cream), antioxidant (vitamin E pill) and so on. According to the different causes of pigmentation, chloasma, age spots and freckles are mainly categorized in the clinic, and the treatment is mainly based on medication and physical therapy. 1. Drug treatment: (1) Vitamin A acid drugs can affect the metabolism of melanin and have certain auxiliary therapeutic effect on chloasma and age spots on the face, such as vitamin A acid ointment. 2. Decolorizers are the first-line drugs used to treat melasma, and the more commonly used drugs include 2%~5% hydroquinone cream. 3. Antioxidant drugs can improve skin texture and lighten the effect of pigmentation, which are often used in the adjuvant treatment of chloasma and age spots in clinic, and the more commonly used drugs are vitamin E pills. 2. Physical therapy mainly includes laser therapy and intense pulse light therapy, which is commonly used for some patients with persistent melasma. As there are individual differences in treatment effect, it is necessary to follow the doctor’s instruction before choosing medication.