Positive antinuclear antibody suggests that the patient may have systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis and dry syndrome, etc. It is recommended to consult the rheumatology and immunology department in a timely manner for a clear diagnosis and early treatment. Antinuclear antibody, i.e. anti-nucleic acid antigen antibody, is mainly found in human serum. Positive antinuclear antibody is associated with autoimmune diseases such as systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis and dry syndrome. However, positive antinuclear antibodies cannot confirm the diagnosis of the above diseases, and patients with positive antinuclear antibodies still need to improve CRP, blood sedimentation, rheumatoid factor, autoantibodies, CT, X-ray and other auxiliary examinations. Clinical manifestations and signs should be combined to make a clear diagnosis. Laboratory test results need to be interpreted by a professional physician, and it is recommended that patients go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.