Dry and itchy skin in winter may be caused by sebum deficiency and eczema, which are usually treated with topical and oral medications. Sebum deficiency is related to cold, dry and other environmental factors, manifested as rough, dry skin, a feeling of tightness, accompanied by varying degrees of itching. 1. Topical medications: Sebum deficiency is usually treated with moisturizing and emollient preparations that do not cause significant irritation, such as urea ointment and vitamin E cream. Patients with eczema due to dryness, manifested as erythema, edema, papules, papules, blisters, vesicles, oozing and other symptoms on the surface of the skin, can be combined with the application of medium-acting glucocorticoid ointment, such as mometasone furoate cream, prednisone acetate cream and so on. 2. Oral medication: If the itching symptoms are severe, accompanied by mossy and hypertrophic lesions, patients with the above diseases can take oral antihistamines, such as loratadine tablets, cetirizine hydrochloride tablets and so on. All of the above drugs have adverse reactions and are recommended to be used under medical supervision. Daily use of mild detergents, avoid over-cleaning, avoid scalding the skin, as well as the frequent use of moisturizing cream, can reduce the loss of skin moisture, to relieve the discomfort of the skin.