Congenital myasthenia gravis syndrome is a myopathy similar to myasthenia gravis, the main difference being that this disease is an inherited muscle disease without the antibodies associated with myasthenia gravis. I have been searching for this disease for more than twenty years, and we have recently diagnosed several patients with good treatment results. The disease develops mostly in infants, with a few onset in childhood or adolescence, and the progression is generally very slow. The so-called clinical manifestations similar to myasthenia gravis are that the patient develops weakness of the eyes, throat, respiratory muscles, and limbs, and the weakness is activity-related, improving with rest and worsening with activity. death due to respiratory failure as a result of pulmonary infection. EMG is normal or myogenic damage is present, and low-frequency repetitive electrical jabs can be seen with a significant frequency decrement. Muscle MRI is generally unremarkable in this disease, serum creatine kinase is normal, and most muscle biopsies are unremarkable, with only a few showing microtubule aggregation within the muscle fibers. In conclusion, the clinical symptoms of this disease are obvious, and various tests do not seem to be significantly abnormal, often misdiagnosed as a chronic fatigue phenomenon. The diagnosis of this disease relies mainly on repetitive electrical nerve stimulation as well as genetic tests. At least 8 genes have been found to be associated with the disease. Treatment can be very effective with the right medications, and we have recently diagnosed and treated a number of patients who have also confirmed that the right choice of medication can yield very good results. The drugs differ for different types of diseases. The current treatment includes: 1. anticholinesterase drugs, which are the same as immune myasthenia gravis but with better results. 2.Salbutamol; 3.Foxetine; 4.Ephedrine hydrochloride 5, quinidine sulfate; 6, 3.4-diaminopyridine. These drugs are generally very cheap, and the last one has a raw material of one dollar a kilogram, which can be used for several years, and no one in the country has made it into a drug. The clinical doctor can think of this disease to save the child’s life, and timely medication in childhood can keep the child in a basically normal state. Attention needs to be paid to this treatable disease.