Congenital myasthenia gravis is a myopathy similar to myasthenia gravis, with the main difference being that it is a genetic muscle disease without antibodies related to myasthenia gravis. The clinical manifestations of the disease are similar to those of myasthenia gravis in that the patient has weakness of the eyes, throat, respiratory muscles, and extremities. death due to respiratory failure as a result of pulmonary infection. EMG is normal or myogenic damage is present, and low-frequency repetitive electrical jabs can be seen with a significant frequency decrement. Muscle MRI is generally unremarkable in this disease, serum creatine kinase is normal, and most muscle biopsies are unremarkable, with only a few showing microtubule aggregation within the muscle fibers. In conclusion, the clinical symptoms of this disease are obvious, and various tests do not seem to be significantly abnormal, often misdiagnosed as a chronic fatigue phenomenon. The diagnosis of this disease relies mainly on repetitive electrical nerve stimulation as well as genetic tests. At least 8 genes have been found to be associated with the disease.