Lumbar discomfort is not necessarily a symptom of uremia, but may also be seen in lumbar muscle strain and other lumbar diseases and nephritis, urinary stones and other urological disorders, so it is necessary to analyze according to the actual condition. Chronic renal failure is a common outcome of all kinds of chronic kidney disease continues to progress to the late stage, it is to metabolite retention, water, electrolyte, acid-base balance imbalance and systemic symptoms for the manifestation of a clinical syndrome; chronic renal failure of the end stage that is uremia; part of the patients with uremia will appear lumbar soreness, lumbar pain and other discomforts, but some patients will not appear lumbar discomfort. Usually, lumbago and lumbar pain can be seen in lumbar muscle strain, lumbar back myofasciitis, lumbar intervertebral disc herniation and other lumbar diseases. In addition, it can also be seen in nephritis, urinary stones, urinary system tumors and other urinary system diseases. Therefore, lumbar discomfort is not a unique symptom of a particular disease, nor is it necessarily a symptom of uremia. The common clinical manifestations of most UTI patients include edema, fatigue, nausea, vomiting, anemia, chest tightness, dyspnea, darkening of the face, itching of the skin, etc. The diagnosis can usually be clarified by means of blood and urine routine, renal function tests, urinalysis and imaging tests of the kidneys. When waist discomfort occurs, it is recommended to consult a doctor in time, and under the guidance of professional doctors, improve the relevant examination to clarify the diagnosis, and then actively standardize the treatment.