High thyroid stimulating hormone in late pregnancy can be categorized into physiological increase, usually without medication; may also be pathologically increased, such as found hypothyroidism, the most commonly used drug treatment is oral thyroid hormone drugs instead of treatment. 1. Physiological increase of thyroid stimulating hormone in late pregnancy:Due to the effect of hCG, the upper and lower limit values of the serum TSH reference range in early pregnancy will show different degrees of decline, and the lower limit value of TSH in a few pregnant women is even lower than the detectable level. Serum TSH gradually rises in mid-pregnancy and may even be higher than in the general population in late pregnancy. In this case, there is no need to use medication, patients are advised to rest more, avoid exertion, and after delivery, the increase in thyroid hormone can subside on its own after the hormone level returns to normal. 2. Pathological increase of thyroid hormone in late pregnancy, such as the occurrence of hypothyroidism, can be given oral thyroid hormone as prescribed by the doctor, from the exogenous supplementation of thyroid hormone, so as to make the pregnant woman’s body thyroid hormone to maintain within the normal range. This will reduce the impact of the disease on the pregnant woman and the fetus. In the course of taking the medication, it is necessary to have regular check-ups and adjust the dosage of the medication according to the doctor’s instructions, so as to keep the thyroid hormone level of the pregnant woman within the normal range. Once the thyroid stimulating hormone level rises in late pregnancy, do not blindly take medication, need to immediately consult a doctor to clarify the cause of the disease and follow the doctor’s instructions to carry out appropriate treatment.