Cough and runny nose at night in babies is considered to be related to physiologic factors as well as diseases such as upper respiratory tract infections and allergic rhinitis. General treatment, medication such as montelukast, mometasone furoate, ephedrine nasal drops, etc. can be given according to different causes for treatment. 1. Physiological factors: if the baby sleeping environment is too dry, it may stimulate the baby’s respiratory mucosa and nasal mucosa, when the mucosa is too dry, it will stimulate the baby to cough and runny nose at night. At this time usually do not need special medication, pay attention to keep the baby sleeping environment humidity can be moderate. 2. upper respiratory tract infection: baby upper respiratory tract infection, at night when sleeping may be due to nasal congestion and cough runny nose phenomenon, can be under the guidance of the doctor to be sea saline nasal spray, dilute nasal secretions, relieve the symptoms of nasal congestion, if necessary, can be added with ephedrine drops to improve nasal edema. 3. Allergic rhinitis: If the baby has allergic rhinitis, it can be due to the nasal secretions backflow stimulation of the throat cough symptoms. Can be prescribed to be montelukast to reduce airway reactivity, mometasone furoate nasal spray anti-inflammatory, loratadine and other anti-allergy treatment. Cough and runny nose at night may also be other causes, such as asthma, gastroesophageal reflux disease, etc., please consult the hospital in time, and active treatment. The above drugs need to follow the doctor’s advice to give medication, do not self-medication in order to avoid danger.