Liposarcoma is a malignant tumor originating from adipocytes and differentiation to adipocytes, and differentiation of mesenchymal cells at different stages of incidence accounts for the 2nd or 3rd highest incidence of soft tissue malignancies. Lipomas are benign tumors most commonly found in the subcutaneous tissues of the back, shoulders, neck and extremities. These two diseases are extremely confusing clinically, so care should be taken to differentiate them during diagnosis. Liposarcoma is a benign tumor most commonly found in the subcutaneous tissues of the back, shoulders, neck and extremities, with envelope, soft texture and yellowish color, resembling normal adipose tissues. Liposarcoma is malignant and common among sarcomas, mostly occurring in the deep soft tissues of the thighs and retroperitoneum. The tumor is nodular or lobulated, with pseudo-envelope on the surface, yellowish in color, resembling adipose tissue, or mucous-like in appearance, or fish-like in shape.