Thickened nails but not gray nails are usually caused by onychomycosis, psoriasis, eczema and so on. It is recommended that the patient be treated with medication, dietary modification, lifestyle improvement and other methods. 1. Inguinitis: It is recommended that serious patients take oral erythromycin or azithromycin as prescribed by the doctor for treatment, and at the same time, apply fusidic acid cream locally for treatment, and pay attention to local cleanliness and hygiene. 2. Psoriasis: patients with psoriasis can also have nail involvement, manifested as thickening of the nails, it is recommended that patients actively treat the primary disease, and at the same time, regular work and rest, do not stay up late, do not drink alcohol, and avoid spicy and stimulating food. 3. Eczema: generally due to chronic eczema caused by nail changes, it is recommended that patients follow the doctor’s instructions to take oral medication such as diclofenac tartaridine, ebastine tablets, etc. for treatment, and pay attention to avoid external stimuli. Nail thickening may also have other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment. The above medications should be used under the guidance of a doctor, avoid self-medication.