Patients often ask, “I used to take extended-release tablets, but now my doctor has changed me to controlled-release tablets, what is the difference between these two dosage forms?” Extended release means that the drug can be released continuously for a longer period of time after administration in order to prolong the efficacy of the drug. Controlled-release formulations are formulations that automatically release the drug at a set rate for a set period of time after administration, so that the blood concentration is maintained at a constant effective concentration for a long time. Whether it is a slow-release formulation or a controlled-release formulation, it has the following advantages: a. For drugs with a short half-life or requiring multiple doses, the number of doses can be reduced, for example, from 3-4 times to 1-2 times per day. This greatly improves the patient’s compliance with the medication, especially for patients with chronic diseases who need to take medication for a long time. Secondly, it provides smooth and long-lasting effective blood concentration, avoids or reduces the peak and trough phenomenon, which is conducive to improving the safety of drug use and reducing the adverse drug reactions. Third, the total dose of the drug can be reduced, so the smallest dose can achieve the maximum effect. Thus, it can be seen that extended-release tablets and controlled-release tablets do not affect the efficacy of the drug, despite their different dosage forms. However, patients need to pay attention to the use of the above two dosage forms of drugs, when taking drugs should be swallowed whole, once chewed, will not play a specific role, and may lead to drug overdose poisoning.