What are nicotine-like and muscarinic symptoms

Both nicotinic-like symptoms and muscarinic-like symptoms belong to the typical clinical signs and symptoms of organophosphorus poisoning: 1. Nicotinic-like symptoms mainly include excessive accumulation of acetylcholine in skeletal muscle and transverse muscle neuromuscular junction, which leads to fibrous-like tremors in the face and eyelids, tongue, limbs, and transverse muscle of the whole body, and even tonic spasms of the whole body muscles, usually with a sense of urgency and pressure throughout the body, at which time, there will be For example, hypertonia, etc. In addition, within the next 2-4 hours, it can also reflexively cause muscle weakness and tetraplegia, and in some severe cases, respiratory muscle paralysis can occur within 24 hours. 2. Muscarinic symptoms are the result of hyperexcitation of parasympathetic nerve endings, which leads to an increase in glandular secretion. Clinical manifestations include nausea, vomiting, abdominal pain, lacrimation, sweating, salivation, diarrhea, urinary and fecal cramps, and fecal incontinence. In addition, pupil pinpoint narrowing and arrhythmia are all muscarinic-like symptoms.