Calluses on toes, mainly caused by long-term friction and pressure, can be relieved by general treatment, medication, and other treatments. 1. General treatment: mainly to do a good job of prevention, need to remove the causes in a timely manner, try to avoid friction and local pressure. You can use hot water to soak the affected area, wait for it to soften, the doctor can use a scalpel blade to scrape off the surface of the stratum corneum. 2. medication: you can use salicylic acid paste, the local surface of the stratum corneum after scraping off, and then cut the paste. Or use the right concentration of urea cream or vitamin A ointment, can promote the skin stratum corneum renewal. 3. Other treatments: For calluses on toes, you can also cooperate with doctors to choose liquid nitrogen freezing and carbon dioxide laser treatment. When suffering from foot deformity, doctors may also give special orthopedic insoles. It is recommended that patients should take into account their own situation, so as to cooperate with the doctor to give the corresponding treatment and therapy, do not blindly deal with their own. It is important to note that all the above medications should be used in accordance with medical advice.