Clinically, the sensitive indicators for early renal failure mainly include retinol-binding protein, cystatin C, β2-microglobulin, urinary microalbumin and α1-microglobulin. For early renal insufficiency, patients often have the clinical manifestation of frequent urination at night, and even this frequent urination, there is more serious than the daytime. Early renal failure may also present with localized loose tissue edema, usually in the eyelids and ankles early in the morning, as well as changes in daily life, such as a decline in physical performance after physical activity. There are also changes in diet, such as intolerance to high-fat and high-salt diets. At the same time, in renal failure, there will be a break in the water-electrolyte balance in the early stage, so the patient’s skin and mucous membranes will also show subtle changes, and it is recommended that the patient undergoes early screening, if there is a clear indicator of constant elevation. Early treatment and intervention of the kidney should be carried out, and if necessary, renal puncture biopsy should be carried out to clarify the type of pathology.